Can I change the regional setting of Windows system running in the E5052B?

No, the default setting is "English (United States)" and the E5052B can not support the other setting.After changing the regional setting to "French(France)" or "German(Germany)", the E5052B display error messages during the start process. "French(France)" and "German(Germany)" setting switch the decimal symbol switches from "." to ",". Therefore, the E5052B will have the trouble to load the calibration data and display error messages.